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Last Updated: September 27, 2020

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Patent: 8,383,857

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Summary for Patent: 8,383,857
Title:Processes for making hydrazides
Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
Inventor(s): Chiarello; George Anello (Morrisonville, NY), Sahli; Ayman (Amman, JO)
Assignee: Wyeth LLC (Madison, NJ)
Application Number:13/360,220
Patent Claims:see list of patent claims

Details for Patent 8,383,857

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Wyeth Pharms Inc BESPONSA inotuzumab ozogamicin POWDER, FOR INJECTION SOLUTION, LYOPHILIZED POWDER 761040 001 2017-08-17   Start Trial Wyeth LLC (Madison, NJ) 2039-10-22 RX Orphan search
Wyeth Pharms Inc MYLOTARG gemtuzumab ozogamicin VIAL;SINGLE-DOSE 761060 001 2018-04-09   Start Trial Wyeth LLC (Madison, NJ) 2039-10-22 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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