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Last Updated: December 6, 2021

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Patent: 8,383,857

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Summary for Patent: 8,383,857
Title:Processes for making hydrazides
Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
Inventor(s): Chiarello; George Anello (Morrisonville, NY), Sahli; Ayman (Amman, JO)
Assignee: Wyeth LLC (Madison, NJ)
Application Number:13/360,220
Patent Claims:see list of patent claims

Details for Patent 8,383,857

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Wyeth Pharmaceuticals Inc. BESPONSA inotuzumab ozogamicin For Injection 761040 2017-08-17 ⤷  Free Forever Trial 2039-10-22
Wyeth Pharmaceuticals Inc. MYLOTARG gemtuzumab ozogamicin For Injection 761060 2017-09-01 ⤷  Free Forever Trial 2039-10-22
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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