Patent: 8,383,857
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Summary for Patent: 8,383,857
| Title: | Processes for making hydrazides |
| Abstract: | A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody. |
| Inventor(s): | Chiarello; George Anello (Morrisonville, NY), Sahli; Ayman (Amman, JO) |
| Assignee: | Wyeth LLC (Madison, NJ) |
| Application Number: | 13/360,220 |
| Patent Claims: | see list of patent claims |
Details for Patent 8,383,857
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Wyeth Pharmaceuticals Llc | BESPONSA | inotuzumab ozogamicin | For Injection | 761040 | 08/17/2017 | ⤷ Try a Trial | 2039-10-22 |
| Wyeth Pharmaceuticals Llc | MYLOTARG | gemtuzumab ozogamicin | For Injection | 761060 | 09/01/2017 | ⤷ Try a Trial | 2039-10-22 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
