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Generated: August 18, 2019

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Patent: 8,383,417

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Summary for Patent: 8,383,417
Title:Assay for monitoring parathyroid hormone (PTH) variants by tandem mass spectrometry
Abstract: Methods are described for monitoring the amounts of PTH variants in a biological sample by digesting the sample to produce surrogate peptides specific to the targeted PTH variants, and detecting and quantifying the surrogate peptides by selective reaction monitoring (SRM) mass spectrometry, using a set of precursor-to-product ion transitions optimized for sensitivity and selectivity. The PTH variants, or a portion thereof, may be concentrated in the sample by means of immunoaffinity capture or other suitable technique. The mass spectrometric method described herein enables the concurrent measurement of peptides representative of a plurality of targeted PTH variants in a single assay.
Inventor(s): Lopez; Mary Frances (Boston, MA), Sarracino; David A. (Andover, MA), Prakash; Amol (Cambridge, MA), Nelson; Randall W. (Phoenix, AZ), Oran; Paul (Scottsdale, AZ), Krastins; Bryan E. (Somerville, MA), Rezai; Taha (Cambridge, MA)
Assignee: Thermo Finnigan, LLC (San Jose, CA) Intrinsic Bioprobes, Inc. (Tempe, AZ)
Application Number:12/644,284
Patent Claims:see list of patent claims

Details for Patent 8,383,417

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Sign Up Thermo Finnigan, LLC (San Jose, CA) Intrinsic Bioprobes, Inc. (Tempe, AZ) 2036-04-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Sign Up Thermo Finnigan, LLC (San Jose, CA) Intrinsic Bioprobes, Inc. (Tempe, AZ) 2036-04-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Sign Up Thermo Finnigan, LLC (San Jose, CA) Intrinsic Bioprobes, Inc. (Tempe, AZ) 2036-04-30 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Sign Up Thermo Finnigan, LLC (San Jose, CA) Intrinsic Bioprobes, Inc. (Tempe, AZ) 2036-04-30 RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source

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