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Last Updated: September 30, 2020

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Patent: 8,377,902

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Summary for Patent: 8,377,902
Title:RNAi compound targeted to thrombospondin-1 and applications thereof
Abstract: The present invention relates to an RNAi compound and an expression plasmid for inhibiting expression of Thrombospondin-1, which comprises a target sequence selected from Thrombospondin-1 gene. The present invention also related to a pharmaceutical composition comprising the RNAi compound and applications thereof. The RNAi compound can reduce the expression of Thrombospondin-1 to activate immune responses. In addition, the present invention also disclosed that an RNAi compound targeted to Thrombospondin-1 gene can delay tumor progression.
Inventor(s): Lai; Ming-Derg (Tainan, TW), Huang; Shih-Shien (Tainan, TW), Yen; Meng-Chi (Tainan, TW), Lin; Chi-Chen (Taichung, TW), Weng; Tzu-Yang (Tainan, TW)
Assignee: National Cheng Kung University (TW)
Application Number:12/985,684
Patent Claims:see list of patent claims

Details for Patent 8,377,902

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial National Cheng Kung University (TW) 2030-01-07 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial National Cheng Kung University (TW) 2030-01-07 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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