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Last Updated: October 1, 2020

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Patent: 8,377,435

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Summary for Patent: 8,377,435
Title:Antibody induced cell membrane wounding
Abstract: Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.
Inventor(s): Bhat; Neelima M. (Los Altos, CA), Bieber; Marcia M. (Los Altos, CA), Teng; Nelson N. H. (Hillsborough, CA), Sanders; Martin E. (Hillsborough, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)
Application Number:11/267,935
Patent Claims:see list of patent claims

Details for Patent 8,377,435

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA) 2024-11-05 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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