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Last Updated: November 29, 2021

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Patent: 8,367,699

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Summary for Patent: 8,367,699
Title:Tetrahydro-isoquinolines
Abstract: The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer\'s Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (A) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections. ##STR00001##
Inventor(s): Weber; Lutz (Germering, DE), Khazak; Vladimir (Brooklyn, NY), Ross; Gunther (Munich, DE), Kalinski; Cedric (Munich, DE), Burdack; Christoph (Munich, DE)
Assignee: NexusPharma, Inc. (Langhorne, PA)
Application Number:12/441,266
Patent Claims:see list of patent claims

Details for Patent 8,367,699

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2026-09-15
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2026-09-15
Clinigen, Inc. PROLEUKIN aldesleukin For Injection 103293 1992-05-05 ⤷  Try it Free 2026-09-15
Amgen, Inc. NEUPOGEN filgrastim Injection 103353 1991-02-20 ⤷  Try it Free 2026-09-15
Amgen, Inc. NEUPOGEN filgrastim Injection 103353 2000-06-28 ⤷  Try it Free 2026-09-15
Partner Therapeutics, Inc. LEUKINE sargramostim For Injection 103362 1991-03-05 ⤷  Try it Free 2026-09-15
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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