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Last Updated: February 18, 2020

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Patent: 8,367,699

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Summary for Patent: 8,367,699
Title:Tetrahydro-isoquinolines
Abstract: The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer\'s Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (A) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections. ##STR00001##
Inventor(s): Weber; Lutz (Germering, DE), Khazak; Vladimir (Brooklyn, NY), Ross; Gunther (Munich, DE), Kalinski; Cedric (Munich, DE), Burdack; Christoph (Munich, DE)
Assignee: NexusPharma, Inc. (Langhorne, PA)
Application Number:12/441,266
Patent Claims:see list of patent claims

Details for Patent 8,367,699

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial NexusPharma, Inc. (Langhorne, PA) 2026-09-15 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial NexusPharma, Inc. (Langhorne, PA) 2026-09-15 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial NexusPharma, Inc. (Langhorne, PA) 2026-09-15 RX search
Chiron PROLEUKIN aldesleukin VIAL 103293 001 1992-05-05   Start Trial NexusPharma, Inc. (Langhorne, PA) 2026-09-15 RX search
Amgen NEUPOGEN filgrastim VIAL 103353 001 1991-02-20   Start Trial NexusPharma, Inc. (Langhorne, PA) 2026-09-15 RX search
Amgen NEUPOGEN filgrastim VIAL 103353 002 1991-02-20   Start Trial NexusPharma, Inc. (Langhorne, PA) 2026-09-15 RX search
Amgen NEUPOGEN filgrastim SYRINGE 103353 003 1991-02-20   Start Trial NexusPharma, Inc. (Langhorne, PA) 2026-09-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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