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Last Updated: September 30, 2020

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Patent: 8,361,467

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Summary for Patent: 8,361,467
Title:Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
Abstract: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-.alpha. synthesis; iii) an inhibitor of membrane-bound TNF-.alpha.; iv) an inhibitor of a natural receptor of TNF-.alpha.; v) an inhibitor of NO synthase, vi) an inhibitor of PLA.sub.2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
Inventor(s): DiMauro; Thomas M. (Southboro, MA), Attawia; Mohamed (Canton, MA), Serhan; Hassan (South Easton, MA), Reynolds; Martin A. (Mansfield, MA), Grace; Melissa (Raynham, MA), Kadiyala; Sudhakar (South Easton, MA), Urbahns; David (Barrington, RI), Bruder; Scott (Sudbury, MA), Collins; Gregory (East Sandwich, MA), Brown; Laura J. (Hamilton Square, NJ), Geesin; Jeff (Doylestown, PA), Plouhar; Pamela L. (South Bend, IN), Smith; Catherine (East Falmouth, MA), Siekierka; John (Towaco, NJ)
Assignee: DePuy Spine, Inc. (Raynham, MA)
Application Number:10/630,227
Patent Claims:see list of patent claims

Details for Patent 8,361,467

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial DePuy Spine, Inc. (Raynham, MA) 2039-02-26 RX Orphan search
Abbvie Inc HUMIRA adalimumab SYRINGE 125057 001 2002-12-31   Start Trial DePuy Spine, Inc. (Raynham, MA) 2039-02-26 RX search
Abbvie Inc HUMIRA adalimumab VIAL 125057 002 2002-12-31   Start Trial DePuy Spine, Inc. (Raynham, MA) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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