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Last Updated: September 29, 2020

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Patent: 8,349,318

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Summary for Patent: 8,349,318
Title:Use of specifically engineered enzymes to enhance the efficacy of prodrugs
Abstract: The invention provides methods for enhancing efficiency of prodrugs by specifically engineered enzymes with altered or enhanced activity and broader substrate specificity towards nucleoside analogs used in cancer chemotherapy, and delivering the enzymes to specific target cells in a patient. The invention also provides modified deoxycytidine kinase (dCK) mutants with such enhanced activities. Furthermore, the invention provides antibody-conjugated enzymes, pharmaceutical composition and kit containing the same, that can be specifically delivered to tumor cells.
Inventor(s): Lavie; Arnon (Chicago, IL), Konrad; Manfred (Gottingen, DE)
Assignee: The Board of Trustees of the University of Illinois (Urbana, IL)
Application Number:12/993,660
Patent Claims:see list of patent claims

Details for Patent 8,349,318

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial The Board of Trustees of the University of Illinois (Urbana, IL) 2028-05-19 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial The Board of Trustees of the University of Illinois (Urbana, IL) 2028-05-19 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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