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Last Updated: December 2, 2021

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Patent: 8,349,318

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Summary for Patent: 8,349,318
Title:Use of specifically engineered enzymes to enhance the efficacy of prodrugs
Abstract: The invention provides methods for enhancing efficiency of prodrugs by specifically engineered enzymes with altered or enhanced activity and broader substrate specificity towards nucleoside analogs used in cancer chemotherapy, and delivering the enzymes to specific target cells in a patient. The invention also provides modified deoxycytidine kinase (dCK) mutants with such enhanced activities. Furthermore, the invention provides antibody-conjugated enzymes, pharmaceutical composition and kit containing the same, that can be specifically delivered to tumor cells.
Inventor(s): Lavie; Arnon (Chicago, IL), Konrad; Manfred (Gottingen, DE)
Assignee: The Board of Trustees of the University of Illinois (Urbana, IL)
Application Number:12/993,660
Patent Claims:see list of patent claims

Details for Patent 8,349,318

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Free Forever Trial 2028-05-19
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Free Forever Trial 2028-05-19
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 2019-02-28 ⤷  Free Forever Trial 2028-05-19
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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