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Generated: September 23, 2019

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Patent: 8,343,995

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Summary for Patent: 8,343,995
Title:Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
Abstract: The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.
Inventor(s): Mosher; Gerold L. (Kansas City, MO), Wedel; Rebecca L. (Lawrence, KS), Johnson; Karen T. (Lawrence, KS), Machatha; Stephen G. (Waltham, MA), Cowee; Jane A. (Kansas City, MO), Cushing; Daniel J. (Phoenixville, PA)
Assignee: Cydex Pharmaceuticals, Inc. (Lenexa, KS)
Application Number:12/597,908
Patent Claims:see list of patent claims

Details for Patent 8,343,995

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22 ➤ Sign Up Cydex Pharmaceuticals, Inc. (Lenexa, KS) 2036-04-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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