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Generated: July 23, 2019

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Patent: 8,329,419

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Summary for Patent: 8,329,419
Title:GLP-1 receptor agonist bioassays
Abstract: Provided herein are cell-based bioassays for measuring GLP-I receptor agonist activity of test compounds, such as GLP-I receptor agonist compounds. Exemplary GLP-I receptor agonist compounds include exendins, exendin analogs, GLP-1(7-37), and GLP-1(7-37) analogs. The bioassays are useful for quantitatively determining cAMP generated in samples containing GLP-I receptor agonist compounds (e.g., exenatide) and 6-23 (clone 6) cells having GLP-I receptors, whereby the amount of cAMP generated can be correlated to the GLP-I receptor agonist activity of the GLP-I receptor agonist compounds (e.g., exenatide). Suitable cell-based bioassays include enzyme-linked immunosorbent assays and homogeneous time-resolved fluorescence assays.
Inventor(s): Nicolaou; Michalis (San Diego, CA), Bancroft; Frederick Charles (Carlsbad, CA), Herich; John Patrick (Cardiff, CA), Gupta; Swati (San Diego, CA), Lwin; Aung Naing (Carlsbad, CA)
Assignee: Amylin Pharmaceuticals, LLC (San Diego, CA) Astrazeneca Pharmaceuticals LP (Wilmington, DE)
Application Number:12/990,693
Patent Claims:see list of patent claims

Details for Patent 8,329,419

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Glaxosmithkline Llc TANZEUM albiglutide INJECTABLE;INJECTION 125431 001 2014-04-15 ➤ Sign Up Amylin Pharmaceuticals, LLC (San Diego, CA) Astrazeneca Pharmaceuticals LP (Wilmington, DE) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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