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Last Updated: July 11, 2020

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Patent: 8,329,419

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Summary for Patent: 8,329,419
Title:GLP-1 receptor agonist bioassays
Abstract: Provided herein are cell-based bioassays for measuring GLP-I receptor agonist activity of test compounds, such as GLP-I receptor agonist compounds. Exemplary GLP-I receptor agonist compounds include exendins, exendin analogs, GLP-1(7-37), and GLP-1(7-37) analogs. The bioassays are useful for quantitatively determining cAMP generated in samples containing GLP-I receptor agonist compounds (e.g., exenatide) and 6-23 (clone 6) cells having GLP-I receptors, whereby the amount of cAMP generated can be correlated to the GLP-I receptor agonist activity of the GLP-I receptor agonist compounds (e.g., exenatide). Suitable cell-based bioassays include enzyme-linked immunosorbent assays and homogeneous time-resolved fluorescence assays.
Inventor(s): Nicolaou; Michalis (San Diego, CA), Bancroft; Frederick Charles (Carlsbad, CA), Herich; John Patrick (Cardiff, CA), Gupta; Swati (San Diego, CA), Lwin; Aung Naing (Carlsbad, CA)
Assignee: Amylin Pharmaceuticals, LLC (San Diego, CA) Astrazeneca Pharmaceuticals LP (Wilmington, DE)
Application Number:12/990,693
Patent Claims:see list of patent claims

Details for Patent 8,329,419

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Sanofi-aventis Us ADLYXIN lixisenatide SOLUTION;SUBCUTANEOUS 208471 002 2016-07-27   Start Trial Amylin Pharmaceuticals, LLC (San Diego, CA) Astrazeneca Pharmaceuticals LP (Wilmington, DE) 2028-05-23 RX search
Sanofi-aventis Us ADLYXIN lixisenatide SOLUTION;SUBCUTANEOUS 208471 001 2016-07-27   Start Trial Amylin Pharmaceuticals, LLC (San Diego, CA) Astrazeneca Pharmaceuticals LP (Wilmington, DE) 2028-05-23 RX search
Glaxosmithkline Llc TANZEUM albiglutide INJECTABLE;INJECTION 125431 001 2014-04-15   Start Trial Amylin Pharmaceuticals, LLC (San Diego, CA) Astrazeneca Pharmaceuticals LP (Wilmington, DE) 2028-05-23 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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