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Last Updated: December 3, 2021

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Patent: 8,288,377

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Summary for Patent: 8,288,377
Title:Inhibitors of the interaction between MDM2 and p53
Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: ##STR00001## wherein n, s, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X, Y, Q, Z, G, E and D have defined meanings.
Inventor(s): Storck; Pierre-Henri (Ramsgate, GB), Schoentjes; Bruno (Bois-Guillaume, FR), Piettre; Arnaud Marcel Pierre (Sierentz, FR), Ermert; Philipp (Allschwil, CH), Poncelet; Virginie Sophie (Le Manoir sur Seine, FR), Csoka; Imre Christian Francis (Louviers, FR)
Assignee: Janssen Pharmaceutica N.V. (Beerse, BE)
Application Number:12/678,680
Patent Claims:see list of patent claims

Details for Patent 8,288,377

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 1978-01-10 ⤷  Try it Free 2027-09-21
Servier Pharmaceuticals Llc ONCASPAR pegaspargase Injection 103411 1994-02-01 ⤷  Try it Free 2027-09-21
Sanofi-aventis U.s. Llc ELITEK rasburicase For Injection 103946 2002-07-12 ⤷  Try it Free 2027-09-21
Sanofi-aventis U.s. Llc ELITEK rasburicase For Injection 103946 2006-01-06 ⤷  Try it Free 2027-09-21
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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