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Last Updated: September 29, 2020

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Patent: 8,288,377

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Summary for Patent: 8,288,377
Title:Inhibitors of the interaction between MDM2 and p53
Abstract: The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: ##STR00001## wherein n, s, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X, Y, Q, Z, G, E and D have defined meanings.
Inventor(s): Storck; Pierre-Henri (Ramsgate, GB), Schoentjes; Bruno (Bois-Guillaume, FR), Piettre; Arnaud Marcel Pierre (Sierentz, FR), Ermert; Philipp (Allschwil, CH), Poncelet; Virginie Sophie (Le Manoir sur Seine, FR), Csoka; Imre Christian Francis (Louviers, FR)
Assignee: Janssen Pharmaceutica N.V. (Beerse, BE)
Application Number:12/678,680
Patent Claims:see list of patent claims

Details for Patent 8,288,377

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Janssen Pharmaceutica N.V. (Beerse, BE) 2027-09-21 RX search
Sigma Tau ONCASPAR pegaspargase VIAL 103411 001 1994-02-01   Start Trial Janssen Pharmaceutica N.V. (Beerse, BE) 2027-09-21 RX search
Sanofi Synthelabo ELITEK rasburicase VIAL; INTRAVENOUS 103946 001 2002-07-12   Start Trial Janssen Pharmaceutica N.V. (Beerse, BE) 2027-09-21 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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