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Last Updated: September 18, 2020

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Patent: 8,277,807

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Summary for Patent: 8,277,807
Title:Pharmaceutical combinations
Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): ##STR00001## or salts, tautomers, solvates and N-oxides thereof; wherein R.sup.1 is hydroxy or hydrogen; R.sup.2 is hydroxy; methoxy or hydrogen; provided that at least one of R.sup.1 and R.sup.2 is hydroxy; R.sup.3 is selected from hydrogen; halogen; cyano; optionally substituted C.sub.1-5 hydrocarbyl and optionally substituted C.sub.1-5 hydrocarbyloxy; R.sup.4 is selected from hydrogen; a group --(O).sub.n--R.sup.7 where n is 0 or 1 and R.sup.7 is an optionally substituted acyclic C.sub.1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C.sub.1-5 hydrocarbyl-amino; or R.sup.3 and R.sup.4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR.sup.5R.sup.6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The combinations have activity as Hsp90 inhibitors.
Inventor(s): Gallagher; Neil James (Basel, CH), Lyons; John Francis (Cambridge, GB), Thompson; Neil Thomas (Cambridge, GB), Yule; Stephen Murray (Cambridge, GB), Murray; Christopher William (Cambridge, GB)
Assignee: Astex Therapeutics Limited (Cambridge, GB)
Application Number:12/445,141
Patent Claims:see list of patent claims

Details for Patent 8,277,807

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 001 1997-11-26   Start Trial Astex Therapeutics Limited (Cambridge, GB) 2026-10-12 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 002 1997-11-26   Start Trial Astex Therapeutics Limited (Cambridge, GB) 2026-10-12 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Astex Therapeutics Limited (Cambridge, GB) 2026-10-12 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07   Start Trial Astex Therapeutics Limited (Cambridge, GB) 2026-10-12 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07   Start Trial Astex Therapeutics Limited (Cambridge, GB) 2026-10-12 RX Orphan search
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 003 2001-05-07   Start Trial Astex Therapeutics Limited (Cambridge, GB) 2026-10-12 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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