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Last Updated: October 1, 2020

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Patent: 8,277,805

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Summary for Patent: 8,277,805
Title:Methods for treating or inhibiting thromboembolic disorders or for inhibiting coagulation
Abstract: The present invention discloses inhibitory antibodies against Factor VIII with modified glycosylation, either by enzymatic deglycosylation or by site directed mutagenesis. Said antibodies with modified glycosylation have equal affinity for FVIII but show different inhibiting properties. The use of one or a mixture of said antibodies allow modulation of the inhibition of factor VIII to levels between 40 and 95%. The present invention further discloses pharmaceutical compositions comprising inhibitory antibodies against Factor VIII with modified glycosylation, combinations of these antibodies and methods for treating haemostasis disorders using said antibodies and antibody mixtures.
Inventor(s): Saint-Remy; Jean-Marie (Grez-Doiceau, BE), Jacquemin; Marc (Sart-Bernard, BE)
Assignee: Life Sciences Research Partners (Leuven, BE)
Application Number:12/732,556
Patent Claims:see list of patent claims

Details for Patent 8,277,805

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22   Start Trial Life Sciences Research Partners (Leuven, BE) 2023-08-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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