Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. ##STR00001##
Belvin; Marcia (South San Francisco, CA), Friedman; Lori (South San Francisco, CA), Hoeflich; Klaus (San Mateo, CA), Sampath; Deepak (San Francisco, CA), Vijapurkar; Ulka (Millbrae, CA), Wallin; Jeffrey (Berkeley, CA), Johnson; Leisa (Point Richmond, CA), Singh; Mallika (San Francisco, CA), Patel; Sonal (Slough, GB)
Genentech, Inc. (South San Francisco, CA) F. Hoffman-La Roche AG (Basel, CH)
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