In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a polynucleotide encoding a therapeutic agent. The gutless adenoviral vector contains the nucleotide sequence of SEQ ID NO:13 or SEQ ID NO:15 and expresses the therapeutic agent in a kidney tissue of the subject.
Sehgal; Lakshman R. (Monarch Beach, CA), Wong; Jonathan (Palot Alto, CA)
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