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Generated: September 22, 2019

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Patent: 8,217,046

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Summary for Patent: 8,217,046
Title:Cinnamoyl-piperazine derivatives and their use as PAR-1 antagonists
Abstract: The present invention relates to compounds of general formula (I): ##STR00001## wherein: R.sub.1 represents: halogen, CN or NO.sub.2; R.sub.2 represents: hydrogen or halogen; n represents: 1 or 2; R.sub.3 represents: phenyl substituted by one or more halogens or C.sub.1-C.sub.6 alkyls; or a cyclohexyl; as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (PAR-1) antagonists, particularly in the treatment of thrombosis.
Inventor(s): Perez; Michel (Castres, FR), Lamothe; Marie (Castres, FR), Le Grand; Bruno (Lautrec, FR), Letienne; Robert (Castres, FR)
Assignee: Pierre Fabre Medicament (Boulogne-Billancourt, FR)
Application Number:12/305,584
Patent Claims:see list of patent claims

Details for Patent 8,217,046

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22   Try a Free Trial Pierre Fabre Medicament (Boulogne-Billancourt, FR) 2026-06-19 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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