Fully human anti-VEGF antibodies and methods of using
Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.
Ramachandra; Sumant (Northbrook, IL), Bishop; Walter Robert (Pompton Plains, NJ), Masat; Linda (Walnut Creek, CA), Huang; Chao Bai (San Leandro, CA), Takeuchi; Toshihiko (Oakland, CA), Kantak; Seema (Pacifica, CA), Huang; Chin-Yi (Fremont, CA)
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