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Last Updated: September 20, 2020

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Patent: 8,188,033

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Summary for Patent: 8,188,033
Title:Anti-microbial peptidomimetic compounds and methods to calculate anti-microbial activity
Abstract: This invention encompasses synthetic antimicrobial peptide analogs having certain un-natural amino acids, including the un-natural amino acids hydrophobic tetrahydroisoquinolinecarboxylic acid (Tic) and octahydroindolecarboxylic acid (Oic), incorporated into the polypeptide backbone. These antimicrobial peptides (AMPs) are useful to treat infection in humans and other mammals of such bacteria as Gram positive bacteria, Gram negative bacteria and Mycobacterium. Many of the AMPs also exhibit the property of reduced hemolytic activity. The invention also entails 3D-QSAR models and mathematical equations that calculate the biological activity of any peptide sequence against Staphylococcus aureus or Mycobacterium ranae.
Inventor(s): Hicks; Rickey P. (Greenville, NC), Venugopal; Diva Karamenon (Gaithersburg, MD), Bhonsle; Jayendra (Germantown, MD)
Application Number:12/004,397
Patent Claims:see list of patent claims

Details for Patent 8,188,033

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Emergent Biodefense Operations Lansing, Llc BIOTHRAX bacillus anthracis INJECTION, SUSPENSION 103821 1 1970-11-04   Start Trial 2026-12-21 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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