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Last Updated: December 6, 2021

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Patent: 8,168,568

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Summary for Patent: 8,168,568
Title:Combinatorial therapy for protein signaling diseases
Abstract: A method for selecting combinations of drugs for treatment of diseases that arise from deranged signaling pathways is disclosed. The method involves measuring the activity states for signaling proteins in a diseased cell and determining whether the activity states are different from the activity states observed for a reference cell such as a normal cell. Based on the observed differences, combinations of two or more drugs are selected to reduce these differences. Treatment of a subject with the combinations restores the activity states of the signaling proteins of the deranged disease-associated signaling pathways toward the activity states observed in the reference cell. Since the diseased cell and the reference cell can both be obtained from the same subject, combinations of drugs that specifically target patient-specific signaling derangements is possible.
Inventor(s): Mehta; Arpita I. (Hoffman Estates, IL), Liotta; Lance A. (Bethesda, MD), Petricoin; Emanuel F. (Gainesville, VA)
Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services (Washington, DC) N/A (N/A)
Application Number:12/581,019
Patent Claims:see list of patent claims

Details for Patent 8,168,568

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Free Forever Trial 2023-03-10
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Free Forever Trial 2023-03-10
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 2019-02-28 ⤷  Free Forever Trial 2023-03-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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