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Last Updated: September 30, 2020

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Patent: 8,163,523

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Summary for Patent: 8,163,523
Title:Cell-based systems for producing influenza vaccines
Abstract: The present invention relates to a cell-based method for producing influenza virus vaccines by enriching the population of surface-bound .alpha.2,6-sialic acid receptors on a cell surface, such as on a Chinese Hamster Ovary (CHO) cell surface. The host cell therefore presents numerous binding sites to which an influenza virus can bind via its hemagglutinin spike protein and infect the host cell. In contrast to wild-type CHO cells, the surface of the mutated CHO cells of the present invention contains an enriched population of .alpha.2,6-sialic acid receptors which makes the inventive CHO cells highly susceptible to viral infection, and therefore safe, effective, and highly efficient cells for rapidly producing influenza vaccines.
Inventor(s): Bilsel; Pamuk (Madison, WI), Kawaoka; Yoshihiro (Middleton, WI), Neumann; Gabriele (Madison, WI)
Assignee: Flugen, Inc. (Madison, WI)
Application Number:12/481,402
Patent Claims:see list of patent claims

Details for Patent 8,163,523

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Glaxosmithkline Biologicals Sa FLUARIX QUADRIVALENT influenza virus vaccine SUSPENSION 125127 1 2020-07-02   Start Trial Flugen, Inc. (Madison, WI) 2028-06-11 search
Id Biomedical Corporation Of Quebec FLULAVAL QUADRIVALENT influenza virus vaccine SUSPENSION 125163 1 2020-07-02   Start Trial Flugen, Inc. (Madison, WI) 2028-06-11 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Colorcon
McKesson
Medtronic
Baxter
Express Scripts
AstraZeneca

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