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Generated: September 22, 2019

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Patent: 8,158,573

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Summary for Patent: 8,158,573
Title:Therapeutic and diagnostic conjugates for use with multispecific antibodies
Abstract: Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
Inventor(s): McBride; William J. (Boonton, NJ), Goldenberg; David M. (Mendham, NJ), Noren; Carl (Elizabeth, NJ), Hansen; Hans J. (Picayune, MS)
Assignee: Immunomedics, Inc. (Morris Plains, NJ)
Application Number:12/138,065
Patent Claims:see list of patent claims

Details for Patent 8,158,573

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Try a Free Trial Immunomedics, Inc. (Morris Plains, NJ) 2018-10-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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