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Last Updated: September 30, 2020

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Patent: 8,137,919

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Summary for Patent: 8,137,919
Title:Method of determining the sensitivity of cancer cells to EGFR inhibitors including cetuximab, panitumumab and erlotinib
Abstract: A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by the following steps: (a) Obtaining cells from a cancer patient\'s tumor; (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and 20 of the PIK3CA gene or which show loss of PTEN protein expression will be considered not likely to benefit from EGFR targeting therapies.
Inventor(s): Mariadason; John M. (Balwyn, AU), Goel; Sanjay (Syosset, NY)
Assignee: Montefiore Medical Center (Bronx, NY)
Application Number:12/384,826
Patent Claims:see list of patent claims

Details for Patent 8,137,919

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Montefiore Medical Center (Bronx, NY) 2028-04-10 RX Orphan search
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 001 2006-09-27   Start Trial Montefiore Medical Center (Bronx, NY) 2028-04-10 RX search
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 002 2006-09-27   Start Trial Montefiore Medical Center (Bronx, NY) 2028-04-10 RX search
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 003 2006-09-27   Start Trial Montefiore Medical Center (Bronx, NY) 2028-04-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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