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Last Updated: September 21, 2020

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Patent: 8,088,762

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Summary for Patent: 8,088,762
Title:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
Abstract: The invention describes novel nitrosated nonsteroidal anti-inflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.
Inventor(s): Earl; Richard A. (Westford, MA), Ezawa; Maiko (Acton, MA), Fang; Xinqin (Lexington, MA), Garvey; David S. (Dover, MA), Gaston; Ricky D. (Malden, MA), Khanapure; Subhash P. (Clinton, MA), Letts; L. Gordon (Dover, MA), Lin; Chia-En (Concord, MA), Ranatunge; Ramani R. (Lexington, MA), Richardson; Stewart K. (Tolland, CT), Schroeder; Joseph D. (Minneapolis, MN), Stevenson; Cheri A. (Haverhill, MA), Wey; Shiow-Jyi (Billerica, MA)
Assignee: NiCox S.A. (Sophia Antipolis, FR)
Application Number:12/636,316
Patent Claims:see list of patent claims

Details for Patent 8,088,762

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial NiCox S.A. (Sophia Antipolis, FR) 2022-07-03 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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