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Generated: August 24, 2019

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Patent: 8,084,575

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Summary for Patent: 8,084,575
Title:Millisecond activation switch for seven-transmembrane proteins
Abstract: The present invention relates to recombinant seven-transmembrane receptor, whereby the amino terminus of said recombinant receptor is located on an extracellular side and the carboxy-terminus is located on an intracellular side of a membrane, comprising at least two detectable labels, whereby a first of said at least two detectable labels is or is located on the carboxy-terminus and whereby a second of said at least two labels is or is located on the first or third intracellular loop or whereby a first of said at least two labels is or is located on the third intracellular loop. Furthermore, nucleic acid molecules encoding said recombinant seven-transmembrane receptors are described as well as vector and host cells comprising the same. Furthermore, the present invention provides for identification and screening methods for molecules or compounds which are capable of modifying the biological end of pharmacological function of seven-transmembrane receptor proteins. Finally, diagnostic compositions comprising the compounds of the present invention as well as kits comprising said compounds are disclosed.
Inventor(s): Bunemann; Moritz (Waldbuttelbrunn, DE), Vilardaga; Jean-Pierre (Wurzburg, DE), Hoffmann; Carsten (Leinach, DE), Lohse; Martin Johannes (Wurzburg, DE)
Assignee: Julius-Maximilians-Universitat (Wurzburg, DE)
Application Number:10/538,985
Patent Claims:see list of patent claims

Details for Patent 8,084,575

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Sign Up Julius-Maximilians-Universitat (Wurzburg, DE) 2022-12-20 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Sign Up Julius-Maximilians-Universitat (Wurzburg, DE) 2022-12-20 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Sign Up Julius-Maximilians-Universitat (Wurzburg, DE) 2022-12-20 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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