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Last Updated: December 3, 2021

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Patent: 8,080,575

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Summary for Patent: 8,080,575
Title:Gamma-lactam compounds for promoting bone growth
Abstract: The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each R.sup.1 and R.sup.2 is H, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkoxy, --OR.sup.4, --NR.sup.4R.sup.5, --SR.sup.4, --C(O)R.sup.4, --C(O)OR.sup.4, --C(O)NR.sup.4R.sup.5, --N(R.sup.4)C(O)R.sup.5, --N(R.sup.4)C(O)OR.sup.5, --N(R.sup.4)C(O)NR.sup.4R.sup.5, --OP(O)(OR.sup.4).sub.2, --S(O).sub.2OR.sup.4, --S(O).sub.2NR.sup.4R.sup.5, --CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R.sup.4 and R.sup.5 is H or C.sub.1-6 alkyl. X is O, S or NR.sup.4. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention.
Inventor(s): Ellies; Debra (Parkville, MO), Rosenberg; William (Overland Park Drive, KS)
Assignee: Osteogenex Inc. (Kansas City, KS)
Application Number:12/472,134
Patent Claims:see list of patent claims

Details for Patent 8,080,575

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Amgen, Inc. PROLIA denosumab Injection 125320 2010-06-01 ⤷  Try it Free 2028-05-29
Amgen, Inc. XGEVA denosumab Injection 125320 2010-11-18 ⤷  Try it Free 2028-05-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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