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Generated: September 22, 2019

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Patent: 8,080,575

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Summary for Patent: 8,080,575
Title:Gamma-lactam compounds for promoting bone growth
Abstract: The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each R.sup.1 and R.sup.2 is H, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.1-6 haloalkoxy, --OR.sup.4, --NR.sup.4R.sup.5, --SR.sup.4, --C(O)R.sup.4, --C(O)OR.sup.4, --C(O)NR.sup.4R.sup.5, --N(R.sup.4)C(O)R.sup.5, --N(R.sup.4)C(O)OR.sup.5, --N(R.sup.4)C(O)NR.sup.4R.sup.5, --OP(O)(OR.sup.4).sub.2, --S(O).sub.2OR.sup.4, --S(O).sub.2NR.sup.4R.sup.5, --CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R.sup.4 and R.sup.5 is H or C.sub.1-6 alkyl. X is O, S or NR.sup.4. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention.
Inventor(s): Ellies; Debra (Parkville, MO), Rosenberg; William (Overland Park Drive, KS)
Assignee: Osteogenex Inc. (Kansas City, KS)
Application Number:12/472,134
Patent Claims:see list of patent claims

Details for Patent 8,080,575

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Amgen PROLIA denosumab INJECTABLE; SUBCUTANEOUS 125320 001 2010-06-01   Try a Free Trial Osteogenex Inc. (Kansas City, KS) 2028-05-29 RX Orphan search
Amgen XGEVA denosumab INJECTABLE; SUBCUTANEOUS 125320 002 2010-06-01   Try a Free Trial Osteogenex Inc. (Kansas City, KS) 2028-05-29 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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