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Last Updated: September 30, 2020

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Patent: 8,080,518

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Summary for Patent: 8,080,518
Title:Co-administration of an agent linked to an internalization peptide with an anti-inflammatory
Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.
Inventor(s): Tymianski; Michael (Toronto, CA), Garman; Jonathan David (San Jose, CA)
Assignee: Arbor Vita Corporation (Fremont, CA) Nono Inc. (Toronto, Ontario, CA)
Application Number:12/323,915
Patent Claims:see list of patent claims

Details for Patent 8,080,518

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial Arbor Vita Corporation (Fremont, CA) Nono Inc. (Toronto, Ontario, CA) 2027-12-05 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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