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Last Updated: September 18, 2020

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Patent: 8,080,404

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Summary for Patent: 8,080,404
Title:Enzymatic decontamination
Abstract: Compositions and methods for enzymatic decontamination by inactivation of Hazardous agents are provided. Hazardous agents of microbial and chemical origin can be neutralized by H.sub.2O.sub.2. The methods described herein provide for enzymatic production of H.sub.2O.sub.2 in situ using oxidoreductase enzymes that use oxygen as an acceptor and their alcohol substrates. The enzymatically produced H.sub.2O.sub.2 and corresponding aldehydes have potent antimicrobial properties. The enzymatically produced H.sub.2O.sub.2 also can detoxify chemical agents in situ. The decontaminating power of the oxidoreductase enzymes that use oxygen as an acceptor may be amplified by addition of reagents, such as acetyl donors or base catalysts that, in the presence of H.sub.2O.sub.2, yield peroxy acid derivatives and hydroperoxy anions. Such derivatives can neutralize biological and chemical agents, thus providing a broadly applicable decontamination method. In addition, catalytic production of H.sub.2O.sub.2 in situ results in controlled synthesis of decontamination reagents at their point of use, mitigating the need to store, transport and dispose of hydrogen peroxide solutions in the field.
Inventor(s): Turetsky; Abraham L. (Baltimore, MD), Pawlowski; David R. (Bel Air, MD), Brickhouse; Mark D. (Newark, DE)
Assignee: The United States of America as represented by the Secretary of the Army (Washington, DC)
Application Number:11/328,477
Patent Claims:see list of patent claims

Details for Patent 8,080,404

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Emergent Biodefense Operations Lansing, Llc BIOTHRAX bacillus anthracis INJECTION, SUSPENSION 103821 1 1970-11-04   Start Trial The United States of America as represented by the Secretary of the Army (Washington, DC) 2025-04-05 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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