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Last Updated: September 27, 2020

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Patent: 8,057,818

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Summary for Patent: 8,057,818
Title:Methods of making expandable foam-like biomaterials
Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
Inventor(s): Yuksel; K. Umit (Kennesaw, GA), Bird; Ana T. (Achworth, GA), Black; Kirby S. (Achworth, GA)
Assignee: CryoLife, Inc. (Kennesaw, GA)
Application Number:11/042,181
Patent Claims:see list of patent claims

Details for Patent 8,057,818

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Grifols Usa, Llc PLASBUMIN albumin (human) SOLUTION 101138 1 1994-09-26   Start Trial CryoLife, Inc. (Kennesaw, GA) 2020-11-07 search
Baxalta Us Inc. FLEXBUMIN albumin human INJECTION, SOLUTION 101452 1 2014-07-31   Start Trial CryoLife, Inc. (Kennesaw, GA) 2020-11-07 search
Csl Behring Ag ALBURX albumin (human) SOLUTION 102366 1 2009-01-06   Start Trial CryoLife, Inc. (Kennesaw, GA) 2020-11-07 search
Grifols Usa, Llc ALBUTEIN albumin (human) INJECTION, SOLUTION 102478 1 2019-12-15   Start Trial CryoLife, Inc. (Kennesaw, GA) 2020-11-07 search
Grifols Usa, Llc HUMAN ALBUMIN GRIFOLS albumin (human) SOLUTION 103352 1 2003-06-11   Start Trial CryoLife, Inc. (Kennesaw, GA) 2020-11-07 search
Csl Behring Llc ALBUMINAR-25 albumin (human) SOLUTION 103955 1 2009-01-06   Start Trial CryoLife, Inc. (Kennesaw, GA) 2020-11-07 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Medtronic

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