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Last Updated: September 28, 2020

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Patent: 8,017,836

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Summary for Patent: 8,017,836
Title:Expression of plasminogen and microplasminogen in duckweed
Abstract: The present invention provides methods and compositions for the production of recombinant plasminogen, microplasminogen, and fragments thereof in a duckweed expression system. It is the novel finding of the present invention that a duckweed expression system may be used to produce high levels of plasminogen and microplasminogen. The duckweed-produced plasminogen and microplasminogen can be activated to produce a polypeptide having protease activity. Thus, the invention encompasses methods for the expression of plasminogen, microplasminogen, and fragments thereof in duckweed, duckweed plants that are transformed with expression cassettes for the expression of plasminogen, microplasminogen, and fragments thereof, and nucleic acids comprising nucleotide sequences encoding plasminogen, microplasminogen, and fragments thereof, where these nucleotide sequences are modified to enhance their expression in duckweed.
Inventor(s): Spencer; David (Chapel Hill, NC), Dickey; Lynn F. (Cary, NC), Gasdaska; John R. (Carrboro, NC), Wang; Xiaowei (Carrboro, NC), Cox; Kevin M. (Raleigh, NC), Peele; Charles G. (Apex, NC)
Assignee: Biolex Therapeutics, Inc. (Pittsboro, NC)
Application Number:12/644,640
Patent Claims:see list of patent claims

Details for Patent 8,017,836

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Biolex Therapeutics, Inc. (Pittsboro, NC) 2024-02-11 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Biolex Therapeutics, Inc. (Pittsboro, NC) 2024-02-11 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Biolex Therapeutics, Inc. (Pittsboro, NC) 2024-02-11 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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