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Generated: July 22, 2019

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Patent: 8,012,476

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Summary for Patent: 8,012,476
Title:Molecules with extended half-lives, compositions and uses thereof
Abstract: The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.
Inventor(s): Dall\'Acqua; William (Gaithersburg, MD), Johnson; Leslie S. (Germantown, MD), Ward; Elizabeth Sally (Dallas, TX)
Assignee: MedImmune, LLC (Gaithersburg, MD) Board of Regents, The University of Texas System (Austin, TX)
Application Number:12/691,433
Patent Claims:see list of patent claims

Details for Patent 8,012,476

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Medimmune SYNAGIS palivizumab VIAL 103770 002 1998-06-19 ➤ Try a Free Trial MedImmune, LLC (Gaithersburg, MD) Board of Regents, The University of Texas System (Austin, TX) ➤ Try a Free Trial RX search
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19 ➤ Try a Free Trial MedImmune, LLC (Gaithersburg, MD) Board of Regents, The University of Texas System (Austin, TX) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 8,012,476

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 02060919 Aug 08, 2002
World Intellectual Property Organization (WIPO) 02060919 Jan 03, 2003
World Intellectual Property Organization (WIPO) 02060919 Sep 04, 2003
United States of America 2003190311 Oct 09, 2003
United States of America 2006198840 Sep 07, 2006
United States of America 2007122403 May 31, 2007
United States of America 2008181887 Jul 31, 2008
Country Patent Number Publication Date

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Serving hundreds of leading biopharmaceutical companies globally:

Farmers Insurance
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Merck
Harvard Business School

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