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Last Updated: November 29, 2021

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Patent: 8,012,476

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Summary for Patent: 8,012,476
Title:Molecules with extended half-lives, compositions and uses thereof
Abstract: The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.
Inventor(s): Dall\'Acqua; William (Gaithersburg, MD), Johnson; Leslie S. (Germantown, MD), Ward; Elizabeth Sally (Dallas, TX)
Assignee: MedImmune, LLC (Gaithersburg, MD) Board of Regents, The University of Texas System (Austin, TX)
Application Number:12/691,433
Patent Claims:see list of patent claims

Details for Patent 8,012,476

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Swedish Orphan Biovitrum Ab (publ) SYNAGIS palivizumab For Injection 103770 1998-06-19 ⤷  Try it Free 2020-12-12
Swedish Orphan Biovitrum Ab (publ) SYNAGIS palivizumab Injection 103770 2004-07-23 ⤷  Try it Free 2020-12-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Harvard Business School
Johnson and Johnson
Express Scripts

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