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Generated: July 20, 2019

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Patent: 8,008,447

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Summary for Patent: 8,008,447
Title:Crystallization of antibody or fragment thereof
Abstract: The present disclosure concerns methods of crystallization and/or concentration of antibody or antibody fragments. The methods comprise contacting an antibody or antibody fragment with a solution comprising a salt of a divalent cation. Crystals and/or protein gels of antibody or antibody fragments are useful in compositions and formulations.
Inventor(s): Hagewiesche; Annette Marie Clasen (Carlsbad, CA), Fukami; Julie (Woodside, CA), Cromwell; Mary E. M. (Redwood City, CA), Dinges; Rachel Bulotsky (San Mateo, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:11/572,369
Patent Claims:see list of patent claims

Details for Patent 8,008,447

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26 ➤ Try a Free Trial Genentech, Inc. (South San Francisco, CA) ➤ Try a Free Trial RX search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26 ➤ Try a Free Trial Genentech, Inc. (South San Francisco, CA) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 8,008,447

Country Patent Number Publication Date
South Africa 200700947 Jun 25, 2008
World Intellectual Property Organization (WIPO) 2006012500 Apr 20, 2006
World Intellectual Property Organization (WIPO) 2006012500 Feb 02, 2006
World Intellectual Property Organization (WIPO) 2006012500 Mar 02, 2006
United States of America 2007258975 Nov 08, 2007
Russian Federation 2007106853 Sep 10, 2008
Country Patent Number Publication Date

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