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Generated: September 18, 2019

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Patent: 8,003,375

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Summary for Patent: 8,003,375
Title:Qualitative differential screening
Abstract: The invention concerns a method for identifying and/or cloning nucleic acid regions representing qualitative differences associated with alternative splicing events and/or with insertions, deletions located in RNA transcribed genome regions, between two physiological situations, comprising either hybridization of RNA derived from the test situation with cDNA\'s derived from the reference situation and/or reciprocally, or double-strand hybridization of cDNA derived from the test situation with cDNA\'s derived from the reference situation; and identifying and/or cloning nucleic acids representing qualitative differences. The invention also concerns compositions or banks of nucleic acids representing qualitative differences between two physiological situations, obtainable by the above method, and their use as probe, for identifying genes or molecules of interest, or still for example in methods of pharmacogenomics, and profiling of molecules relative to their therapeutic and/or toxic effects. The invention further concerns the use of dysregulation of splicing RNA as markers for predicting molecule toxicity and/or efficacy, and as markers in pharmacogenomics.
Inventor(s): Schweighoffer; Fabien (Vincennes, FR), Bracco; Laurent (Paris, FR), Tocque; Bruno (Courbevoie, FR)
Assignee: ExonHit Therapeutics S.A. (Paris, FR)
Application Number:12/622,364
Patent Claims:see list of patent claims

Details for Patent 8,003,375

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Try a Free Trial ExonHit Therapeutics S.A. (Paris, FR) 2018-03-11 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Try a Free Trial ExonHit Therapeutics S.A. (Paris, FR) 2018-03-11 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Try a Free Trial ExonHit Therapeutics S.A. (Paris, FR) 2018-03-11 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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