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Last Updated: October 1, 2020

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Patent: 7,998,926

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Summary for Patent: 7,998,926
Title:Dimerized T-cell receptor fragment, its compositions and use
Abstract: Dimers of a peptide from the T-cell receptor (Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr) (SEQ ID NO:1) are disclosed for preventing the progression to AIDS in an animal model. Methods for delaying the progression to AIDS and restoring normal immunological responses in an animal model following infection are shown and comprise administering through various systemic routes dimeric T-cell receptor peptide V.beta. CDR1 to restore normal levels of Th1 cytokines interleukin 2 and interferon-.gamma., which are suppressed following infection, and those of Th2 derived cytokines interleukin 5, interleukin 6, interleukin 10, and immunoglobulin G, which are stimulated following infection.
Inventor(s): Marchalonis; John Jacob (Tucson, AZ), Watson; Ronald Ross (Tucson, AZ)
Assignee: The Arizona Boad of Regents on Behfl of the University of Arizona (Tucson, AZ)
Application Number:10/478,194
Patent Claims:see list of patent claims

Details for Patent 7,998,926

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial The Arizona Boad of Regents on Behfl of the University of Arizona (Tucson, AZ) 2021-05-18 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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