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Last Updated: September 29, 2020

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Patent: 7,998,477

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Summary for Patent: 7,998,477
Title:Spherical protein particles and methods for making and using them
Abstract: This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals.
Inventor(s): Yakovlevsky; Kirill (Cambridge, MA), Shamashkin; Michael (Somerville, MA), Khalaf; Nazer (Worcester, MA), Govardhan; Chandrika P. (Lexington, MA), Jung; Chu W. (Arlington, MA)
Assignee: Althea Technologies Inc. (San Diego, CA)
Application Number:10/741,861
Patent Claims:see list of patent claims

Details for Patent 7,998,477

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22   Start Trial Althea Technologies Inc. (San Diego, CA) 2021-06-21 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 001 1997-11-26   Start Trial Althea Technologies Inc. (San Diego, CA) 2021-06-21 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 002 1997-11-26   Start Trial Althea Technologies Inc. (San Diego, CA) 2021-06-21 RX search
Novartis SIMULECT basiliximab VIAL; SINGLE-USE 103764 001 1998-05-12   Start Trial Althea Technologies Inc. (San Diego, CA) 2021-06-21 RX search
Novartis SIMULECT basiliximab VIAL; SINGLE-USE 103764 002 1998-05-12   Start Trial Althea Technologies Inc. (San Diego, CA) 2021-06-21 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19   Start Trial Althea Technologies Inc. (San Diego, CA) 2021-06-21 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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