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Generated: September 24, 2019

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Patent: 7,993,638

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Summary for Patent: 7,993,638
Title:Cancer treatment combining lymphodepleting agent with CTLs and cytokines
Abstract: In a cancer treatment combining cell therapy with chemotherapy, autologous CD8.sup.+ T cells are obtained from a patient, activated ex vivo by contacting them with xenogenic antigen presenting cells loaded with selected peptide antigen, thereby generating antigen-specific activated cytotoxic T lymphocytes. Such activated CTLs are administered to the patient in conjunction with a lymphodepletion and CTL maintenance regimen comprising a non-myeloblative but lymphdepleting agent, such as cladribine or denileukin diftitox, and interleukin-2 and interferon-.alpha.-2b stimulatory cytokines.
Inventor(s): Cai; Zeling (San Diego, CA), Moriarty; Ann (Poway, CA), Peterson; Per A. (Rancho Santa Fe, CA), Richards; Jon M. (Glenview, IL)
Assignee: Janssen Pharmaceutica NV (BE)
Application Number:12/281,197
Patent Claims:see list of patent claims

Details for Patent 7,993,638

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Eisai Inc ONTAK denileukin diftitox VIAL 103767 001 1999-02-05   Try a Free Trial Janssen Pharmaceutica NV (BE) 2026-03-01 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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