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Last Updated: September 27, 2020

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Patent: 7,981,421

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Summary for Patent: 7,981,421
Title:Combinations of antibodies selective for DR5 and other therapeutic agents
Abstract: An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
Inventor(s): Zhou; Tong (Birmingham, AL), Ichikawa; Kimihisa (Kanagawa-ken, JP), Kimberly; Robert P. (Birmingham, AL), Koopman; William J. (Indian Springs, AL), Ohsumi; Jun (Kanagawa-ken, JP), LoBuglio; Albert F. (Birmingham, AL), Buchsbaum; Donald J. (Alabaster, AL)
Assignee: The UAB Research Foundation (Birmingham, AL)
Application Number:12/686,659
Patent Claims:see list of patent claims

Details for Patent 7,981,421

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial The UAB Research Foundation (Birmingham, AL) 2020-05-02 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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