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Last Updated: September 24, 2020

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Patent: 7,964,566

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Summary for Patent: 7,964,566
Title:Monomethylvaline compounds capable of conjugation to ligands
Abstract: Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
Inventor(s): Doronina; Svetlana O. (Snohomish, WA), Senter; Peter D. (Seattle, WA), Toki; Brian E. (Shoreline, WA), Ebens; Allen J. (San Carlos, CA), Kline; Toni Beth (Seattle, WA), Polakis; Paul (Burlingame, CA), Sliwkowski; Mark X. (San Carlos, CA), Spencer; Susan D. (Tiburon, CA)
Assignee: Seattle Genetics, Inc. (Bothell, WA)
Application Number:11/833,959
Patent Claims:see list of patent claims

Details for Patent 7,964,566

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Seattle Genetics, Inc. (Bothell, WA) 2023-11-06 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial Seattle Genetics, Inc. (Bothell, WA) 2023-11-06 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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