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Last Updated: July 11, 2020

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Patent: 7,956,167

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Summary for Patent: 7,956,167
Title:Purification of collagenases from clostridium histolyticum liquid culture
Abstract: The present invention provides a method for purifying Clostridium histolyticum collagenase type I and type II proteins from a complex mixture by subsequently performing a precipitation with ammonium sulfate, hydrophobic interaction chromatography, cation exchange chromatography, and anion chromatography. Conditions are provided which lead to a stabilized, partially purified preparation even after the precipitation step. The method of the invention leads to a quick and efficient removal of other proteolytic activities. The preparations according to the invention provide exceptionally pure and intact collagenase type I and type II proteins which are enzymatically active. The invention also provides blends of the two isolated proteins. The invention further provides the use of the purified collagenase proteins or blends thereof for treating a tissue sample in vitro.
Inventor(s): Hoelke; Werner (Penzberg, DE), Eckstein; Hellmut (Weilheim, DE), Fischer; Michaela (Wolfratshausen, DE), Liehre; Antje (Penzberg, DE), Suppmann; Bernhard (Weilheim, DE), Thalhofer; Johann-Peter (Weilheim, DE)
Assignee: Roche Diagnostics Operations, Inc. (Indianapolis, IN)
Application Number:12/474,488
Patent Claims:see list of patent claims

Details for Patent 7,956,167

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Roche Diagnostics Operations, Inc. (Indianapolis, IN) 2028-06-02 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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