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Last Updated: September 30, 2020

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Patent: 7,951,356

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Summary for Patent: 7,951,356
Title:Tissue factor compositions and kits for coagulation and tumor treatment
Abstract: The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulant-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVIIa activators.
Inventor(s): Thorpe; Philip E. (Dallas, TX), King; Steven W. (Foothill Ranch, CA), Gao; Boning (Dallas, TX)
Assignee: Board of Regents, The University of Texas System (Austin, TX)
Application Number:09/573,835
Patent Claims:see list of patent claims

Details for Patent 7,951,356

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Board of Regents, The University of Texas System (Austin, TX) 2017-01-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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