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Last Updated: September 18, 2020

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Patent: 7,919,251

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Summary for Patent: 7,919,251
Title:Non-thiopurine methyltransferase related effects in 6-mercaptopurine therapy
Abstract: The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. In particular, the present invention provides methods for predicting a patient\'s risk of an adverse drug reaction (or tolerance) to a 6-mercaptopurine drug by genotyping a patient at a polymorphic site in at least one gene selected from the group consisting of a xanthine dehydrogenase (XDH) gene, molybdenum cofactor sulfurase (MOCOS) gene, and aldehyde oxidase (AOX) gene. The present invention further provides methods for optimizing therapeutic efficacy in a patient receiving a 6-mercaptopurine drug by determining whether the patient should be given an alternative drug based on the presence or absence of a polymorphism in at least one of the XDH, MOCOS, and AOX genes.
Inventor(s): Sanderson; Jeremy D. (London, GB), Marinaki; Anthony M. (London, GB), Smith; Melissa A. (Hampshire, GB)
Assignee: Guy\'s and St. Thomas\' NHS Foundation Trust (London, GB)
Application Number:12/248,866
Patent Claims:see list of patent claims

Details for Patent 7,919,251

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial Guy\'s and St. Thomas\' NHS Foundation Trust (London, GB) 2027-10-12 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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