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Last Updated: September 26, 2020

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Patent: 7,910,337

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Summary for Patent: 7,910,337
Title:Method for identifying drug-sensitizing antisense DNA fragments and use thereof
Abstract: The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a template; fragmentation of the DNA by sonication or other means; selecting DNA fragments no longer than 400 base pairs; ligating the DNA fragments into a suitable expression plasmid with a selectable marker; transforming the plasmids containing the DNA fragments into the organism from which the gene of interest originated; and selecting clones from transformed cells that show a phenotypic difference of the clone grown in the presence of the inducer relative to the phenotype in the absence of inducer.
Inventor(s): Haselbeck; Robert (San Diego, CA), Hilgers; Mark (San Diego, CA), Shaw; Karen (Poway, CA), Brown-Driver; Vickie (Solana Beach, CA), Gc; Kedar (San Diego, CA), Finn; John M. (Encinitas, CA), Stidham; Mark (San Diego, CA)
Assignee: Trius Therapeutics, Inc. (San Diego, CA)
Application Number:11/636,394
Patent Claims:see list of patent claims

Details for Patent 7,910,337

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Emergent Biodefense Operations Lansing, Llc BIOTHRAX bacillus anthracis INJECTION, SUSPENSION 103821 1 1970-11-04   Start Trial Trius Therapeutics, Inc. (San Diego, CA) 2026-03-15 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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