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Last Updated: February 21, 2020

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Patent: 7,901,905

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Summary for Patent: 7,901,905
Title:Gene expression system based on codon translation efficiency
Abstract: The present invention discloses a method for modulating the production of a protein from a polynucleotide in a CHO cell by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower translation efficiency in the CHO cell than the codon it replaces, or by introducing into the CHO cell a polynucleotide that codes for an iso-tRNA which limits the rate of production of the polypeptide and which corresponds to a codon of the first polynucleotide. The present invention also discloses the use of a protein-encoding polynucleotide whose codon composition has been modified for enhanced production of the protein in CHO cells.
Inventor(s): Frazer; Ian Hector (Queensland, AU)
Assignee: The University of Queensland (St. Lucia, Queensland, AU)
Application Number:11/077,939
Patent Claims:see list of patent claims

Details for Patent 7,901,905

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial The University of Queensland (St. Lucia, Queensland, AU) 2022-09-13 RX Orphan search
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial The University of Queensland (St. Lucia, Queensland, AU) 2022-09-13 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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