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Last Updated: November 29, 2021

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Patent: 7,901,905

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Summary for Patent: 7,901,905
Title:Gene expression system based on codon translation efficiency
Abstract: The present invention discloses a method for modulating the production of a protein from a polynucleotide in a CHO cell by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower translation efficiency in the CHO cell than the codon it replaces, or by introducing into the CHO cell a polynucleotide that codes for an iso-tRNA which limits the rate of production of the polypeptide and which corresponds to a codon of the first polynucleotide. The present invention also discloses the use of a protein-encoding polynucleotide whose codon composition has been modified for enhanced production of the protein in CHO cells.
Inventor(s): Frazer; Ian Hector (Queensland, AU)
Assignee: The University of Queensland (St. Lucia, Queensland, AU)
Application Number:11/077,939
Patent Claims:see list of patent claims

Details for Patent 7,901,905

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Immunex Corporation ENBREL etanercept For Injection 103795 1998-11-02 ⤷  Try it Free 2022-09-13
Immunex Corporation ENBREL etanercept For Injection 103795 1999-05-27 ⤷  Try it Free 2022-09-13
Immunex Corporation ENBREL etanercept Injection 103795 2004-09-27 ⤷  Try it Free 2022-09-13
Immunex Corporation ENBREL etanercept Injection 103795 2007-02-01 ⤷  Try it Free 2022-09-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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McKinsey

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