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Last Updated: September 19, 2020

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Patent: 7,901,691

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Summary for Patent: 7,901,691
Title:Chimeric G protein based rabies vaccine
Abstract: A novel chimeric protein of rabies virus designed to express a chimeric G protein at a high level in transgenic plants. A gene was also designed and chemically synthesised to encode the chimeric G protein and expressed at high level in plant tissue. The gene was expressed in transgenic tobacco plants to examine its therapeutic efficacy against infection by rabies virus. The chimeric G protein was enriched in plant membranes. The BalbC mice were immunised with the plant leaf expressed G-protein. Plant derived chimeric G protein elicited higher immune response as compared to the commercial vaccine. The mice displayed protective immunity when they were challenged with live virus. Chimeric G protein expressed at high level in plant leaves was demonstrated to function as a commercially valuable subunit vaccine against rabies virus infection.
Inventor(s): Tuli; Rakesh (Uttar Pradesh, IN), Sawant; Samir Vishwanath (Uttar Pradesh, IN), Ashraf; Shadma (Uttar Pradesh, IN), Singh; Pradhyumna Kumar (Uttar Pradesh, IN), Yadav; Dinesh Kumar (Uttar Pradesh, IN), Shahnawaz; Mohammad (Uttar Pradesh, IN), Mishra; Satish (Uttar Pradesh, IN)
Assignee: Council of Scientific and Indistrial Research (New Delhi, IN) Unichem Laboratories Ltd. (Mumbai, IN) Indian Veterinary Research Institute (Izatnagar, IN)
Application Number:11/202,864
Patent Claims:see list of patent claims

Details for Patent 7,901,691

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Glaxosmithkline Biologicals Sa RABAVERT rabies vaccine KIT 103334 1 2016-12-19   Start Trial Council of Scientific and Indistrial Research (New Delhi, IN) Unichem Laboratories Ltd. (Mumbai, IN) Indian Veterinary Research Institute (Izatnagar, IN) 2024-08-13 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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