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Last Updated: September 29, 2020

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Patent: 7,888,490

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Summary for Patent: 7,888,490
Title:Process for the preparation of non-toxic anthrax vaccine
Abstract: Anthrax toxin, comprising of protective antigen (PA), lethal factor (LF) and edema factor (EF) is a major virulent factor of B. anthracis. Protective antigen, PA is the main component of all the vaccines against anthrax. The protective efficacy of PA is greatly increased if small quantities of LF of EF are incorporated into the vaccines. An ideal vaccine against anthrax should contain PA, LF and EF together, but this combination would be toxic. Therefore, the biologically inactive mutant preparations of PA, LF and EF may be used together for better immunoprotection. The present invention describes the method for generation of recombinant vaccine against anthrax, comprising of non-toxic, mutant anthrax toxin proteins. The procedure involves site-directed mutagenesis of the native genes of the toxin proteins, the expression and purification of the mutant proteins and finally characterization of these proteins.
Inventor(s): Bhatnagar; Rakesh (New Delhi, IN), Gupta; Pankaj (New Delhi, IN), Batra; Smriti (New Delhi, IN), Chauhan; Vibha (New Delhi, IN), Singh; Aparna (New Delhi, IN), Ahuja; Nidhi (New Delhi, IN), Kumar; Praveen (New Delhi, IN)
Assignee: Centre of Biotechnology Jawaharlal Nehru University (New Delhi, IN)
Application Number:10/497,673
Patent Claims:see list of patent claims

Details for Patent 7,888,490

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Emergent Biodefense Operations Lansing, Llc BIOTHRAX bacillus anthracis INJECTION, SUSPENSION 103821 1 1970-11-04   Start Trial Centre of Biotechnology Jawaharlal Nehru University (New Delhi, IN) 2021-12-05 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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