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Last Updated: September 30, 2020

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Patent: 7,887,833

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Summary for Patent: 7,887,833
Title:Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting
Abstract: An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.
Inventor(s): Heldman; Eliahu (Rehovot, IL), Linder; Charles (Rehovot, IL), Grinberg; Sarina (Meitar, IL), Kolot; Victoria (Beer-Sheva, IL), Shaubi; Eleonora (Beer-Sheva, IL)
Assignee: Ben-Gurion University of the Negev Research and Development Authority (Beer-Sheva, IL)
Application Number:10/497,705
Patent Claims:see list of patent claims

Details for Patent 7,887,833

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Ben-Gurion University of the Negev Research and Development Authority (Beer-Sheva, IL) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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