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Generated: September 19, 2019

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Patent: 7,884,264

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Summary for Patent: 7,884,264
Title:Compositions and methods for inhibition of fucosyltransferase and xylosyltransferase expression in duckweed plants
Abstract: Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. In some embodiments, the methods comprise introducing into a duckweed plant a recombinant RNAi construct that provides for the inhibition of expression of .alpha.1,3-fucosyltransferase (FucT) and .beta.1,2-xylosyltransferase (XylT). Use of these RNAi constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a \"humanized\" N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants, including duckweed plants, having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the G0 glycoform, are also provided.
Inventor(s): Dickey; Lynn F. (Cary, NC), Cox; Kevin M. (Raleigh, NC), Peele; Charles G. (Apex, NC)
Assignee: Biolex Therapeutics, Inc. (Pittsboro, NC)
Application Number:11/624,164
Patent Claims:see list of patent claims

Details for Patent 7,884,264

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up Biolex Therapeutics, Inc. (Pittsboro, NC) 2026-01-17 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up Biolex Therapeutics, Inc. (Pittsboro, NC) 2026-01-17 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up Biolex Therapeutics, Inc. (Pittsboro, NC) 2026-01-17 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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