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Generated: August 22, 2019

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Patent: 7,858,389

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Summary for Patent: 7,858,389
Title:Selection of non-small-cell lung cancer patients for treatment with monoclonal antibody drugs targeting EGFR pathway
Abstract: Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer (NSCLC) patient is likely to benefit from a monoclonal antibody drug targeting an epidermal growth factor receptor pathway. A mass spectrum is obtained from a sample (e.g. blood sample) from the patient. One or more predefined pre-processing steps are performed on the mass spectrum. Values of selected features in the spectrum at one or more predefined m/z ranges are obtained after the pre-processing steps have been performed. Such values are used in a classification algorithm using a training set comprising class-labeled spectra produced from samples from other patients to identify the patient as being likely to benefit from treatment with the drug.
Inventor(s): Roder; Heinrich (Steamboat Springs, CO), Tsypin; Maxim (Steamboat Springs, CO), Grigorieva; Julia (Steamboat Springs, CO)
Assignee: Biodesix, Inc. (Steamboat Springs, CO)
Application Number:12/321,392
Patent Claims:see list of patent claims

Details for Patent 7,858,389

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 003 2006-09-27 ➤ Sign Up Biodesix, Inc. (Steamboat Springs, CO) 2026-03-31 RX search
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 002 2006-09-27 ➤ Sign Up Biodesix, Inc. (Steamboat Springs, CO) 2026-03-31 RX search
Amgen VECTIBIX panitumumab INJECTABLE; IV (INFUSION) 125147 001 2006-09-27 ➤ Sign Up Biodesix, Inc. (Steamboat Springs, CO) 2026-03-31 RX search
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18 ➤ Sign Up Biodesix, Inc. (Steamboat Springs, CO) 2026-03-31 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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International Patent Family for US Patent 7,858,389

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2007126758 Jan 10, 2008
World Intellectual Property Organization (WIPO) 2007126758 Nov 08, 2007
World Intellectual Property Organization (WIPO) 2010085234 Jul 29, 2010
World Intellectual Property Organization (WIPO) 2010085235 Jul 29, 2010
United States of America 2007231921 Oct 04, 2007
>Country >Patent Number >Publication Date

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