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Generated: August 19, 2019

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Patent: 7,846,427

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Summary for Patent: 7,846,427
Title:Stabilized interferon liquid formulations
Abstract: Stabilized liquid pharmaceutical composition comprising an interferon (IFN) or an isoform, mutein, fused protein, functional derivative, active fraction or salt thereof, wherein said formulation is a solution that comprises a buffer, a cyclodextrin, an isotonicity agent and an anti-oxidant are described here. Preferably the interferon is interferon beta-1a and the cyclodextrin is HPBCD. These formulations are stable at room temperature, thus bringing the advantage of lower costs for formulation storage and increased safety for the patient with respect to possible \"errors\" during handling. As a matter of fact, having such formulations stable at room temperature reduces the risk of formation of degradation products potentially responsible for adverse events (e.g. immunogenicity).
Inventor(s): Del Curto; Maria Dorly (Corvino San Quicico, IT)
Assignee: Ares Trading S.A. (Aubonne, CH)
Application Number:10/582,027
Patent Claims:see list of patent claims

Details for Patent 7,846,427

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Serono Inc REBIF interferon beta-1a SYRINGE 103780 002 2002-03-07   Try a Free Trial Ares Trading S.A. (Aubonne, CH) 2023-12-11 RX search
Serono Inc REBIF interferon beta-1a SYRINGE 103780 001 2002-03-07   Try a Free Trial Ares Trading S.A. (Aubonne, CH) 2023-12-11 RX search
Biogen AVONEX interferon beta-1a VIAL 103628 001 1996-05-17   Try a Free Trial Ares Trading S.A. (Aubonne, CH) 2023-12-11 RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source

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