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Last Updated: November 28, 2021

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Patent: 7,846,427

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Summary for Patent: 7,846,427
Title:Stabilized interferon liquid formulations
Abstract: Stabilized liquid pharmaceutical composition comprising an interferon (IFN) or an isoform, mutein, fused protein, functional derivative, active fraction or salt thereof, wherein said formulation is a solution that comprises a buffer, a cyclodextrin, an isotonicity agent and an anti-oxidant are described here. Preferably the interferon is interferon beta-1a and the cyclodextrin is HPBCD. These formulations are stable at room temperature, thus bringing the advantage of lower costs for formulation storage and increased safety for the patient with respect to possible \"errors\" during handling. As a matter of fact, having such formulations stable at room temperature reduces the risk of formation of degradation products potentially responsible for adverse events (e.g. immunogenicity).
Inventor(s): Del Curto; Maria Dorly (Corvino San Quicico, IT)
Assignee: Ares Trading S.A. (Aubonne, CH)
Application Number:10/582,027
Patent Claims:see list of patent claims

Details for Patent 7,846,427

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Biogen Inc. AVONEX interferon beta-1a For Injection 103628 1996-05-17 ⤷  Free Forever Trial 2023-12-11
Biogen Inc. AVONEX interferon beta-1a Injection 103628 2003-05-28 ⤷  Free Forever Trial 2023-12-11
Biogen Inc. AVONEX interferon beta-1a Injection 103628 2012-02-27 ⤷  Free Forever Trial 2023-12-11
Emd Serono, Inc. REBIF interferon beta-1a Injection 103780 2002-03-07 ⤷  Free Forever Trial 2023-12-11
Emd Serono, Inc. REBIF interferon beta-1a Injection 103780 2004-12-17 ⤷  Free Forever Trial 2023-12-11
Emd Serono, Inc. REBIF interferon beta-1a Injection 103780 2012-12-21 ⤷  Free Forever Trial 2023-12-11
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Baxter
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Merck
Medtronic
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