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Last Updated: March 29, 2024

Patent: 7,834,019


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Summary for Patent: 7,834,019
Title:Substituted pyrazolo[3,4-d]pyrimidinone derivatives
Abstract: The invention relates to compounds of a general formula (I): ##STR00001## wherein Ar.sup.1 is an optionally-substituted aryl or heteroaromatic group; R.sup.1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R.sup.2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of --N(R.sup.1k)R.sup.1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
Inventor(s): Sagara; Takeshi (Tsukuba, JP), Otsuki; Sachie (Tsukuba, JP), Sunami; Satoshi (Toride, JP), Sakamoto; Toshihiro (Moriya, JP), Niiyama; Kenji (Tsuchiura, JP), Yamamoto; Fuyuki (Tsukuba, JP), Yoshizumi; Takashi (Ushiku, JP), Furuyama; Hidetomo (Tsukuba, JP), Goto; Yasuhiro (Tsukuba, JP), Bamba; Makoto (Tsukuba, JP), Takahashi; Keiji (Tsukuba, JP), Hirai; Hiroshi (Tsukuba, JP), Nishibata; Toshihide (Tsukuba, JP)
Assignee: Banyu Pharmaceutical Co., Ltd. (Chiyoda-Ku, Tokyo, JP)
Application Number:11/789,548
Patent Claims:see list of patent claims

Details for Patent 7,834,019

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genzyme Corporation THYROGEN thyrotropin alfa For Injection 020898 11/30/1998 ⤷  Try a Trial 2026-04-27
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 01/10/1978 ⤷  Try a Trial 2026-04-27
Clinigen, Inc. PROLEUKIN aldesleukin For Injection 103293 05/05/1992 ⤷  Try a Trial 2026-04-27
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 ⤷  Try a Trial 2026-04-27
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 02/19/2002 ⤷  Try a Trial 2026-04-27
Eisai, Incorporated ONTAK denileukin diftitox Injection 103767 02/05/1999 ⤷  Try a Trial 2026-04-27
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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