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Generated: September 19, 2019

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Patent: 7,829,297

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Summary for Patent: 7,829,297
Title:Treatment of cancers expressing p95 ErbB2
Abstract: The truncated ErbB2 receptor (p95.sup.ErbB2) is shown to differ from the full-length ErbB2 receptor in its association with other ErbB receptors. The truncated receptor preferentially associated with ErbB3, whereas full length ErbB2 heterodimerizes with either EGFR or ErbB3. Consistent with p95.sup.ErbB2 heterodimerization with ErbB3, it is shown that heregulin (an ErbB3 ligand) stimulates p95.sup.ErbB2 phosphorylation in breast cancer cell lines. Described herein are methods of identifying patients suitable for treatment with a p95.sup.ErbB2 inhibitor, and methods of treating such patients.
Inventor(s): Spector; Neil Lee (Durham, NC), Xia; Wenle (Durham, NC)
Assignee: GlaxoSmithKline LLC (Philadelphia, PA)
Application Number:12/366,457
Patent Claims:see list of patent claims

Details for Patent 7,829,297

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25 ➤ Sign Up GlaxoSmithKline LLC (Philadelphia, PA) 2024-08-02 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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