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Last Updated: October 1, 2020

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Patent: 7,815,907

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Summary for Patent: 7,815,907
Title:Antibodies to insulin-like growth factor I receptor
Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
Inventor(s): Cohen; Bruce D (East Lyme, CT), Beebe; Jean (Salem, CT), Miller; Penelope E (Mystic, CT), Moyer; James D (East Lyme, CT), Corvalan; Jose R (Foster City, CA), Gallo; Michael (North Vancouver, CA)
Assignee: Amgen Fremont Inc. (Fremont, CA) Pfizer Inc. (New York, NY)
Application Number:11/144,248
Patent Claims:see list of patent claims

Details for Patent 7,815,907

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Octapharma Usa Inc CUTAQUIG immunoglobulin g SOLUTION 125668 1 2019-05-03   Start Trial Amgen Fremont Inc. (Fremont, CA) Pfizer Inc. (New York, NY) 2021-01-05 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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